Synthesis and anti-mycobacterial activity of glycosyl sulfamides of arabinofuranose.
نویسندگان
چکیده
A series of arabino N-glycosyl sulfamides, forced to adopt the furanose form by removal of the 5-hydroxyl group, were synthesised as putative isosteric mimics of decaprenolphosphoarabinose, the donor processed by arabinosyltransferases during mycobacterial cell wall assembly. Compounds showed moderate anti-mycobacterial activity, which was maximal for a C10 sulfamide side chain.
منابع مشابه
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 5 شماره
صفحات -
تاریخ انتشار 2016